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How Kratom Works - Alkaloids

In comparison to many other medicinal plants and pharmaceutical medications, kratom is very unique. The majority of this plant’s uniqueness stems from the large range of different alkaloids that are found within this plant’s leaves. In this short post we hope to show you the range of different alkaloids this plant has and their unique effects.

7-hydroxymitragynine

In terms of effects, 7-OHM is by far the most potent. This alkaloid gives kratom the majority of its potent painkilling effects, euphoric effects and sedating effects. This alkaloid is primarily an opiod, but is much safer than any other known opiods, and has much less side effects.

Mitragynine

This is by far one of the most well-known and most abundant of all alkaloids found within the kratom plant. This alkaloids has both stimulating, painkilling and euphoric effects. This is due to its actions as both an mu-opiod agonist and actions it has at the adrenergic (adrenaline) receptors. The levels of this alkaloid have a large impact on whether a given strain is stimulating or sedating.
Although we don’t know too much about this alkaloid, those pharmacologically interested can find some more helpful information on it here.

Mitraphylline
Although typically found a much lower levels than the above two alkaloids, mitraphylline acts as a potent muscle relaxant, blood pressure lowerer and immune system stimulant, and has a fair impact on the qualities of a particular strain.

Speciogynine
This alkaloid typically comprises about 7% of all alkaloids found within the kratom leaf and functions as a muscle relaxant. Because the eye contains some smooth muscles for control, it may have an impact on the “wobbles” commonly spoken of.
All of these different alkaloids have an impact on the quality and effects of the kratom plant, and there are many more alkaloids found in small levels which have additional impact, making each strain very unique.